What can clinical immunology learn from inborn errors of epigenetic regulators?

The epigenome is at the interface between environmental factors and genome, regulating gene transcription, DNA repair, replication. Epigenetic modifications play a crucial role in establishing maintaining cell identity are especially for neurology, musculoskeletal integrity, function of immune system. Mutations genes encoding components epigenetic machinery lead to development distinct disorders, involving central nervous system host defense. In this review, we focus on By studying phenotype patients with monogenic mutations (inborn errors regulators), demonstrate importance methylation, histone modifications, chromatin remodeling, noncoding RNAs, mRNA processing immunity. Moreover, give short overview therapeutic strategies targeting epigenome. Every body has an identical yet different cells have functions maintain their expression profile as they divide. This cellular retained by processes. Epigenetics term that refers heritable changes without modifying sequence itself.1Bird A. 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